The mechanism of action of CELEBREX is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of cyclooxygenase-2 (COX-2), and at therapeutic
Put another way, it is a COX-2 inhibitor
Pharmacology: Pharmacodynamics: The mechanism of action of Celecoxib is via inhibition of prostaglandin synthesis primarily by inhibition of COX-2
Summary
The main mechanism of action of NSAIDs is the inhibition of the enzyme cyclooxygenase (COX)
This activity reviews the indications, action, and contraindications for COX inhibitors as valuable agents in the management of a variety of different pain syndromes in many various diseases
1 Only for ages > 2 years old; 4 Special Populations
OA 200 mg/day as a single dose or 100 mg bid
Naproxen blocks arachidonate binding to competitively inhibit both cyclooxygenase (COX) isoenzymes, COX-1 and COX-2, resulting in analgesic and anti-inflammatory effects
Celiprolol: Rofecoxib may decrease the antihypertensive activities of Celiprolol Celecoxib inhibits the classic COX-2/PGE 2 signal axis and affects some downstream pathways or mechanisms (such as Akt, NF-κb, STAT3, MMP), and inhibits tumor proliferation and metastasis
Celecoxib: The risk or severity of nephrotoxicity can be increased when Celecoxib is The mechanism of action of celecoxib is believed to be due to inhibition of prostaglandin synthesis, primarily via inhibition of COX-2
Pharmacology: Pharmacodynamics: The mechanism of action of Celecoxib is via inhibition of prostaglandin synthesis primarily by inhibition of COX-2
Diagram Legend
The pharmacology and mechanisms of action of the NSAIDs will be reviewed here
These enzymes are involved in cell-wall synthesis and cell division
The pharmacology and mechanisms of action of the NSAIDs, including aspirin, will be reviewed here
Parecoxib is a COX2 selective inhibitor in the same category as celecoxib (Celebrex) and rofecoxib (Vioxx)
Celecoxib is used to treat the pain associated with osteoarthritis, rheumatoid arthritis (including juvenile), and ankylosing spondylitis